Which of the following is an early sign of Parkinson's disease?

• A. Difficulty in breathing
• B. Change in handwriting
• C. Extreme fatigue
• D. Loss of appetite

Answer: (B)

A change in handwriting is considered an early sign of Parkinson's disease, often referred to as micrographia. This phenomenon is characterized by writing that becomes smaller and more cramped over time, which is a consequence of the motor difficulties associated with the condition. Parkinson's disease primarily affects the motor system, leading to rigidity, bradykinesia (slowness of movement), and tremors. As these symptoms evolve, they can affect fine motor skills, such as writing.

In contrast, while the other options may exhibit with Parkinson's disease, they are not early signs specifically linked to it. Difficulty in breathing may arise due to complications related to the disease but is not typically considered an initial symptom. Extreme fatigue may occur as a result of the disease's progression or its overall impact on the body, but again, it does not serve as a primary early indicator. Loss of appetite can happen due to various factors, including medication side effects or depression, yet it is also not one of the hallmark early signs associated with Parkinson's disease. Thus, the change in handwriting is a specific and identifiable early symptom that many healthcare providers recognize as an important aspect of diagnosing Parkinson's.